Linked Life Data

8093688

Source:http://linkedlifedata.com/resource/pubmed/id/8093688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-2-19
pubmed:abstractText
The surfactant Cremophor EL has recently been shown to reverse the multiple drug resistance phenotype (mdr1) created by over-expression of P glycoprotein, an ATP dependent membrane transport system. Oxidize glutathione and glutathione thioethers are transported out of cells by ATP dependent systems that are distinct from the P glycoprotein pathway. The present study shows that Cremophor EL and a number of other polyethoxylated surfactants inhibit the transport of 2,4-dinitrophenyl glutathione out of intact erythrocytes. The inhibition is not complete, suggesting that this inhibition may differentiate between different glutathione transporters. ATP concentrations are maintained within the cells incubated with Cremophor EL indicating that the inhibition is not mediated by metabolic deprivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
315
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
298-300
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Inhibition of erythrocyte glutathione conjugate transport by polyethoxylated surfactants.
pubmed:affiliation
Molecular Genetics Group, John Curtin School of Medicine Research, Australian National University, Canberra.
pubmed:publicationType
Journal Article