Linked Life Data

8093467

Source:http://linkedlifedata.com/resource/pubmed/id/8093467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-11
pubmed:abstractText
The recovery kinetics for split-dose, multifractionated and continuous irradiations were considered in the framework of the DSB model (Ostashevsky 1989) with the assumption of a cooperative type of DSB repair. Two types of in vitro split-dose experiments can be distinguished on the basis of the time of cell plating: (i) IP, where cells are plated immediately after the second dose; and (ii) DP, where cells are incubated for a long period after the second dose before plating. The model predicts that the IP split-dose recovery kinetics depend mainly on the first dose and are not described by a single exponential curve. The rate of these recovery kinetics is faster than that of DSB repair. In contrast, the DP split-dose recovery kinetics are dose-independent and described by a single exponential curve, the time constant of which coincides with that for DSB repair. The equation for cell survival after multifractionated and continuous irradiations, derived in this work, are different from those in other models (e.g. incomplete repair (IR)) and represent an alternative which is worth testing. The values of the repair time constant estimated from these equations are at least 1.5-2-fold longer than those estimated from the IR equations applied to the same experimental data.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0955-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-58
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cell recovery kinetics for split-dose, multifractionated and continuous irradiation in the DSB model.
pubmed:affiliation
Department of Radiation Oncology, SUNY-Health Science Center, Brooklyn 11203.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.