| pubmed-article:8093435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0025266 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0019900 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8093435 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:8093435 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8093435 | pubmed:dateCreated | 1993-2-8 | lld:pubmed |
| pubmed-article:8093435 | pubmed:abstractText | Previous studies have shown that exogenous IL-2 does not correct the reduction in phytohaemagglutinin (PHA)-induced proliferation of lymphocytes from HIV-1 infected (HIV+) individuals. We investigated the mechanism of this reduction to determine if reduced expression of the complete IL-2 receptor (IL-2R) was responsible. In a series of experiments, PHA-stimulated lymphocytes from a total of 89 HIV- and 93 HIV+ homosexual men from the Baltimore Multicentre AIDS Cohort Study (MACS) were studied to determine the expression of messages for the alpha and beta subunits of the IL-2R, the binding of 125I-IL-2 to high affinity IL-2R, and the effect of IL-2 on cell proliferation. Compared to HIV- donors, PHA-stimulated lymphocytes from most HIV+ donors demonstrated (i) a reduction in high affinity IL-2R expression that correlated with the reduction in the IL-2-induced proliferative response; and (ii) a reduction in expression of both IL-2R alpha- and beta-chain mRNA which may be responsible for decreased high affinity IL-2R expression. However, lymphocytes from some HIV+ individuals had borderline low IL-2-induced proliferation despite normal or elevated expression of high affinity IL-2R. These results suggest that decreased expression of IL-2R may account, at least in part, for the lower proliferative response of cells from HIV+ donors. | lld:pubmed |
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| pubmed-article:8093435 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8093435 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8093435 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8093435 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8093435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8093435 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8093435 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:AdlerW HWH | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:RajN BNB | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:MargolickJ... | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:ChopraR KRK | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:SaahA JAJ | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:DonnenbergA... | lld:pubmed |
| pubmed-article:8093435 | pubmed:author | pubmed-author:ScallyJ PJP | lld:pubmed |
| pubmed-article:8093435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8093435 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:8093435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8093435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8093435 | pubmed:pagination | 18-24 | lld:pubmed |
| pubmed-article:8093435 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8093435 | pubmed:meshHeading | pubmed-meshheading:8093435-... | lld:pubmed |
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| pubmed-article:8093435 | pubmed:meshHeading | pubmed-meshheading:8093435-... | lld:pubmed |
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| pubmed-article:8093435 | pubmed:meshHeading | pubmed-meshheading:8093435-... | lld:pubmed |
| pubmed-article:8093435 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8093435 | pubmed:articleTitle | Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men. | lld:pubmed |
| pubmed-article:8093435 | pubmed:affiliation | Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205. | lld:pubmed |
| pubmed-article:8093435 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8093435 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8093435 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
