Linked Life Data

8093435

Source:http://linkedlifedata.com/resource/pubmed/id/8093435

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-2-8
pubmed:abstractText
Previous studies have shown that exogenous IL-2 does not correct the reduction in phytohaemagglutinin (PHA)-induced proliferation of lymphocytes from HIV-1 infected (HIV+) individuals. We investigated the mechanism of this reduction to determine if reduced expression of the complete IL-2 receptor (IL-2R) was responsible. In a series of experiments, PHA-stimulated lymphocytes from a total of 89 HIV- and 93 HIV+ homosexual men from the Baltimore Multicentre AIDS Cohort Study (MACS) were studied to determine the expression of messages for the alpha and beta subunits of the IL-2R, the binding of 125I-IL-2 to high affinity IL-2R, and the effect of IL-2 on cell proliferation. Compared to HIV- donors, PHA-stimulated lymphocytes from most HIV+ donors demonstrated (i) a reduction in high affinity IL-2R expression that correlated with the reduction in the IL-2-induced proliferative response; and (ii) a reduction in expression of both IL-2R alpha- and beta-chain mRNA which may be responsible for decreased high affinity IL-2R expression. However, lymphocytes from some HIV+ individuals had borderline low IL-2-induced proliferation despite normal or elevated expression of high affinity IL-2R. These results suggest that decreased expression of IL-2R may account, at least in part, for the lower proliferative response of cells from HIV+ donors.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-1700428, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-1708315, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-1969782, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2137842, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2467293, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2493338, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2556795, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2571670, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2581997, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2582258, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2583751, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2584707, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2784365, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2784485, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2785715, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2787381, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2795714, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2889557, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2961571, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2968871, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2975974, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-2996136, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3003749, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3012540, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3040856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3045818, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3095229, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3108371, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3131876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3161909, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3300281, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-3926900, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-4179068, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6235286, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6422299, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6575385, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6605980, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6606643, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6609030, http://linkedlifedata.com/resource/pubmed/commentcorrection/8093435-6968909
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men.
pubmed:affiliation
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.
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