Linked Life Data

8092434

Source:http://linkedlifedata.com/resource/pubmed/id/8092434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-10-14
pubmed:abstractText
In the present study we evaluated the allergenicity and immunogenicity of a whey partially hydrolysate formula (PHF) in a guinea pig model. Nine groups of 10 guinea pigs received either a conventional milk formula (CMF) or PHF for 37 days. After intravenous (i.v.) challenge with either beta-lactoglobulin (beta-L) or ultracentrifuged (u)CMF, animals fed CMF showed, respectively, 80% and 100% fatal reactions, whereas animals fed PHF showed no reactions when i.v. challenged both with beta-L and uPHF. Eighty percent fatal reactions, and 10%, respectively, of severe and mild reactions have been observed in the CMF-fed, casein-challenge group. In contrast, only one (10%) mild reaction occurred in the PHF-fed, casein-challenged group. When challenged with u-pasteurized cow's milk (uPCM), CMF-fed animals showed 86% fatal reactions and 14% mild reactions, whereas PHF-fed ones presented 70% no reactions, 20% mild reactions, and one (10%) fatal reaction. Animals fed CMF showed a significantly higher level of specific IgG against cow's milk antigens than PHF-fed ones, which, however, presented higher levels of antibodies than a water-supplemented control group. The present results confirm that PHF is less sensitizing than CMF in a guinea pig model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0105-4538
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Ability of a new infant formula prepared from partially hydrolyzed bovine whey to induce anaphylactic sensitization: evaluation in a guinea pig model.
pubmed:affiliation
Pediatric Department, University of Verona, Italy.
pubmed:publicationType
Journal Article, Comparative Study