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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 2
|
| pubmed:dateCreated |
1994-10-19
|
| pubmed:abstractText |
The impact of acute myocardial edema on coronary flow and left ventricular performance was studied in isolated isovolumic rat hearts. After 15 min of aortic perfusion with Krebs-Henseleit buffer, hearts (10/group) were either removed for determination of water content or perfused for another 90 min. Three groups were perfused at a constant pressure of 60, 100, or 140 mmHg, and two groups were perfused at 60 or 140 mmHg with adenosine added. Compared with the 15-min group, there was a significant increase in water content in all groups except the 60-mmHg group (P < 0.005). There was a direct linear relationship between increases in coronary vascular resistance over time and water content (P < 0.0001). A decrease in developed pressure and peak +dP/dt was observed only in those groups that accumulated water. An inverse linear relationship was found between changes in developed pressure and water content (P = 0.0001). Water content had no effect on end-diastolic pressure below 5 ml/g; above 5 ml/g, a direct linear relationship was evident (P = 0.009). The results suggest that myocardial edema increases vascular resistance and decreases systolic performance. End-diastolic pressure is less influenced by edema than either systolic or coronary vascular function.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
267
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H1054-61
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8092270-Acute Disease,
pubmed-meshheading:8092270-Adenosine,
pubmed-meshheading:8092270-Animals,
pubmed-meshheading:8092270-Body Water,
pubmed-meshheading:8092270-Coronary Circulation,
pubmed-meshheading:8092270-Diastole,
pubmed-meshheading:8092270-Edema, Cardiac,
pubmed-meshheading:8092270-Heart,
pubmed-meshheading:8092270-Male,
pubmed-meshheading:8092270-Myocardium,
pubmed-meshheading:8092270-Perfusion,
pubmed-meshheading:8092270-Pressure,
pubmed-meshheading:8092270-Rats,
pubmed-meshheading:8092270-Rats, Sprague-Dawley,
pubmed-meshheading:8092270-Regression Analysis,
pubmed-meshheading:8092270-Time Factors,
pubmed-meshheading:8092270-Vascular Resistance,
pubmed-meshheading:8092270-Ventricular Function, Left
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Effect of acute edema on left ventricular function and coronary vascular resistance in the isolated rat heart.
|
| pubmed:affiliation |
Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|