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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1994-10-19
|
| pubmed:abstractText |
To address the question of HAV prevalence and seroconversion in relation to clotting factor concentrates, we assayed an early serum for 339 hemophiliacs followed every 6 months by the Transfusion Safety Study in the period from mid-1985 until mid-1992. We found 58.4% positive around entry, with an age-specific prevalence that did not vary with age. In comparison to rates for anti-HIV-negative blood donors, they were significantly higher. Based on testing of subsequent sera, 11 hemophiliacs (7.8% of 141 susceptibles) changed their anti-HAV status from negative to positive. In 9 instances, positivity immediately followed the first dose of intravenous immune globulin. A possible seroconversion followed treatment with blood components, and a possible seroconversion followed intermediate-purity, solvent/detergent(SD)-treated factor VIII concentrate. Neither of these 2 patients was anti-HAV IgM positive, so that passively transferred antibody is possible. The high prevalence among hemophiliacs at entry must be further investigated by determining the expected background rate in a US population similar to the hemophilia patients, and by comparing anti-HAV prevalence associated with SD-treated and heat-inactivated concentrates.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0042-9007
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
67 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
24-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8091731-Adolescent,
pubmed-meshheading:8091731-Adult,
pubmed-meshheading:8091731-Age Factors,
pubmed-meshheading:8091731-Blood Component Transfusion,
pubmed-meshheading:8091731-Child,
pubmed-meshheading:8091731-Child, Preschool,
pubmed-meshheading:8091731-HIV Infections,
pubmed-meshheading:8091731-Hepatitis A,
pubmed-meshheading:8091731-Humans,
pubmed-meshheading:8091731-Male,
pubmed-meshheading:8091731-Middle Aged,
pubmed-meshheading:8091731-Prevalence,
pubmed-meshheading:8091731-United States
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Hepatitis A virus transmission by blood products in the United States. Transfusion Safety Study Group.
|
| pubmed:affiliation |
University of Southern California, Los Angeles 90032.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|