Linked Life Data

8091232

Source:http://linkedlifedata.com/resource/pubmed/id/8091232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5181
pubmed:dateCreated
1994-10-20
pubmed:abstractText
The cellular proto-oncogene c-myc is involved in cell proliferation and transformation but is also implicated in the induction of programmed cell death (apoptosis). The same characteristics have been described for the tumor suppressor gene p53, the most commonly mutated gene in human cancer. In quiescent mouse fibroblasts expressing wild-type p53 protein, activation of c-Myc was found to induce apoptosis and cell cycle reentry, preceded by stabilization of p53. In contrast, in quiescent p53-null fibroblasts, activation of c-Myc induced cell cycle reentry but not apoptosis. These results suggest that p53 mediates apoptosis as a safeguard mechanism to prevent cell proliferation induced by oncogene activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
265
pubmed:geneSymbol
c-myc, p53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2091-3
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Mediation of c-Myc-induced apoptosis by p53.
pubmed:affiliation
Institut für Klinische Molekularbiologie und Tumorgenetik Forschungszentrum für Umwelt und Gesundheit, GSF, München, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't