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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1994-10-20
|
| pubmed:abstractText |
For children with acute respiratory infections in hospital, it is desirable to transfer from parenteral to oral therapy at the earliest opportunity. The introduction of a pediatric suspension of cefuroxime axetil provides a continuous course of one antibiotic with transition from injectable to oral therapy. This open study was designed to investigate the efficacy of cefuroxime in pediatric patients aged 3 months to 5 years with community-acquired pneumonia. Children had evidence of lobar pneumonia on chest X-ray, a white blood cell count of > 15,000/mm3 and a rectal temperature of > or = 38.5 degrees C on enrollment. Cefuroxime was given by i.v. injection at 75 mg/kg per day in three divided doses for 48-72 h followed by oral cefuroxime suspension at 30 mg/kg per day in two divided doses. Of 84 evaluable patients 82 (97.6%) were cured or improved post-treatment, and of 74 evaluable children who returned for follow-up assessment 73 (98.6%) remained well. Oral therapy with twice daily cefuroxime axetil suspension following 2-3 days of i.v. cefuroxime administration was confirmed as effective and safe treatment for lobar pneumonia in children under 5 years of age.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0021-2180
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
684-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8088980-Acute Disease,
pubmed-meshheading:8088980-Administration, Oral,
pubmed-meshheading:8088980-Cefuroxime,
pubmed-meshheading:8088980-Child, Preschool,
pubmed-meshheading:8088980-Community-Acquired Infections,
pubmed-meshheading:8088980-Drug Administration Schedule,
pubmed-meshheading:8088980-Female,
pubmed-meshheading:8088980-Follow-Up Studies,
pubmed-meshheading:8088980-Humans,
pubmed-meshheading:8088980-Infant,
pubmed-meshheading:8088980-Infusions, Intravenous,
pubmed-meshheading:8088980-Injections, Intravenous,
pubmed-meshheading:8088980-Leukocyte Count,
pubmed-meshheading:8088980-Male,
pubmed-meshheading:8088980-Pneumonia, Pneumococcal,
pubmed-meshheading:8088980-Prospective Studies,
pubmed-meshheading:8088980-Suspensions,
pubmed-meshheading:8088980-Treatment Outcome
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Cefuroxime efficacy in pneumonia: sequential short-course i.v./oral suspension therapy.
|
| pubmed:affiliation |
Department of Pediatrics, Tel Aviv Sourasky Medical Center (Ichilov Hospital), Israel.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study
|