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rdf:type |
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lifeskim:mentions |
umls-concept:C0021311,
umls-concept:C0023828,
umls-concept:C0030956,
umls-concept:C0039194,
umls-concept:C0065082,
umls-concept:C0072844,
umls-concept:C0085358,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1545588,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1994-10-18
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pubmed:abstractText |
Cytolytic T-cell vaccination with immunodominant MHC class I-restricted peptides contained within Quil A liposomes has been previously demonstrated. In recent years, Quil A has been under consideration for use as an adjuvant in humans. We assessed the possible use of peptide inoculation in the context of Quil A liposomes to be protective in a mouse model. Listeria monocytogenes was used as the challenge pathogen and the previously identified listeriolysin 91-99 peptide as the immunogen. The listeriolysin 91-99 Quil A liposome inoculum showed significant enhancement of survival after challenge with up to 10 times the L. monocytogenes LD50.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemolysin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Quil A,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/hlyA protein, Listeria monocytogenes
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-2478
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8088867-Adjuvants, Immunologic,
pubmed-meshheading:8088867-Animals,
pubmed-meshheading:8088867-Antigens, CD8,
pubmed-meshheading:8088867-Bacterial Toxins,
pubmed-meshheading:8088867-Bacterial Vaccines,
pubmed-meshheading:8088867-Cytotoxicity, Immunologic,
pubmed-meshheading:8088867-Female,
pubmed-meshheading:8088867-Heat-Shock Proteins,
pubmed-meshheading:8088867-Hemolysin Proteins,
pubmed-meshheading:8088867-Immunodominant Epitopes,
pubmed-meshheading:8088867-Liposomes,
pubmed-meshheading:8088867-Listeriosis,
pubmed-meshheading:8088867-Mice,
pubmed-meshheading:8088867-Mice, Inbred BALB C,
pubmed-meshheading:8088867-Oligopeptides,
pubmed-meshheading:8088867-Saponins,
pubmed-meshheading:8088867-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8088867-T-Lymphocytes, Regulatory
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pubmed:year |
1994
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pubmed:articleTitle |
The immunodominant peptide from listeriolysin in Quil A liposomes vaccinates CD8+ cytolytic T cells and confers protection to infection.
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pubmed:affiliation |
Institute for Medical Microbiology, Technical University of Munich, Germany.
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pubmed:publicationType |
Journal Article
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