| pubmed-article:8087864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C1155046 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8087864 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8087864 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8087864 | pubmed:dateCreated | 1994-10-20 | lld:pubmed |
| pubmed-article:8087864 | pubmed:abstractText | Recently, we have shown that T cells exposed to concentrations of prostaglandin E2 (PGE2) or the beta-adrenergic receptor agonist isoproterenol (ISO) that elicit equimolar levels of cAMP accumulation do not inhibit anti-CD3 monoclonal antibody-induced T cell proliferation to the same extent. This report extends these studies by investigating the induction of cAMP-dependent protein kinase (PKA) in T cells stimulated with PGE2 or ISO. The kinetics of PKA activity induced by PGE2 or ISO in T cells are similar but PGE2 induces more PKA activity. When T cells were treated with concentrations of PGE2 or ISO that elicited similar PKA activities, PGE2 was found to be more immunosuppressive than ISO. T cells stimulated with PGE2 or ISO showed similar levels of increased PKA activity in both the cytosolic and the particulate fractions. Quantitation of the activity of PKA I and PKA II isozymes in T cells stimulated with PGE2 or ISO revealed that both types were activated; however, while PGE2 induced the utilization of an equal amount of both isozymes in T cells, ISO-treated cells utilized twice as much PKA I compared to PKA II. Overall, these results suggest that qualitative differences in the concentration of cAMP and PKA activity are important elements in modulatory T cell proliferative responses. | lld:pubmed |
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| pubmed-article:8087864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8087864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8087864 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8087864 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8087864 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8087864 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8087864 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8087864 | pubmed:author | pubmed-author:BrooksW HWH | lld:pubmed |
| pubmed-article:8087864 | pubmed:author | pubmed-author:RoszmanT LTL | lld:pubmed |
| pubmed-article:8087864 | pubmed:author | pubmed-author:BartikM MMM | lld:pubmed |
| pubmed-article:8087864 | pubmed:author | pubmed-author:BaumanG PGP | lld:pubmed |
| pubmed-article:8087864 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8087864 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8087864 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:8087864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8087864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8087864 | pubmed:pagination | 182-94 | lld:pubmed |
| pubmed-article:8087864 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8087864 | pubmed:meshHeading | pubmed-meshheading:8087864-... | lld:pubmed |
| pubmed-article:8087864 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8087864 | pubmed:articleTitle | Induction of cAMP-dependent protein kinase (PKA) activity in T cells after stimulation of the prostaglandin E2 or the beta-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation. | lld:pubmed |
| pubmed-article:8087864 | pubmed:affiliation | Department of Microbiology and Immunology, University of Kentucky Medical Center, Lexington 40536-0084. | lld:pubmed |
| pubmed-article:8087864 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8087864 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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