Linked Life Data

8087581

Source:http://linkedlifedata.com/resource/pubmed/id/8087581

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-10-20
pubmed:abstractText
The central importance of the alveolar epithelial barrier in the pathogenesis and recovery from acute lung injury has only recently been appreciated. Both in vivo and in vitro studies have provided a new understanding of the mechanisms that regulate transport of sodium, water, and protein across the alveolar epithelial barrier. This new information regarding the normal function of the alveolar epithelial barrier in regulating lung fluid and protein balance has made it possible to study the function of the alveolar barrier both experimentally and clinically in the setting of acute lung injury. The alveolar epithelial barrier is much more resistant to injury than the nearby lung endothelium. The mechanisms that cause injury to the alveolar barrier are just beginning to be explored in different experimental models of acute lung injury. Some progress has been made in understanding how alveolar barrier injury occurs, especially in bacterial pneumonia. Finally, while it is recognized that alveolar epithelial type II cells play an important role in both ion transport and surfactant production, it is now possible to study in vitro the contribution of alveolar epithelial type II cells in repair of the denuded alveolar barrier.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1063-7389
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-22
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Alveolar epithelial barrier and acute lung injury.
pubmed:affiliation
Cardiovascular Research Institute, University of California at San Francisco 94143-0130.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review