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pubmed-article:8085167pubmed:abstractTextMonomethoxypolyethylene glycol (MPEG) was attached covalently to superoxide dismutase (SOD, EC1.15.1.1). The molecular weight of MPEG-SOD was about 7.0 x 10(5) Dalton determined by Fast Protein Liquid Chromatography (FPLC with Sepharose 6 HR10/30). MPEG-SOD exhibited a sharply enhanced serum half life (more than 30 h) than that of the native SOD (6-10 min). To determine the role of MPEG-SOD in acute hypoxia-induced injury of left ventricular function, heart rate (HR), arterial pressure (AP), left ventricular pressure (LVP) and dp/dt (LV +/- dp/dtmax) were measured in male SD rats divided into three groups: Control group (n = 8, intravenously injected with physiological saline), native SOD group (n = 8,800 U SOD i. v.) and MPEG-SOD group (n = 9,800 U MPEG-SOD i. v.). LVP, LV +/- dp/dtmax, AP and HR showed no significant difference among these three groups before hypoxia. But in acute hypoxia simulating altitude of 6,000-6,500 m, LVP, LV+dp/dtmax and AP were decreased in the control group, while in MPEG-SOD group they were all increased compared with those in control group (P < 0.05, P < 0.01). There were no significant difference between control group and native SOD group. The results indicate that MPEG-SOD has a protective effect on the injury of myocardial function induced by acute hypoxia, and suggest that acute hypoxia cause increase of superoxide free radical (O2.-) and other derivative radicals damaging membrane system of the cell.lld:pubmed
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pubmed-article:8085167pubmed:authorpubmed-author:ChenMMlld:pubmed
pubmed-article:8085167pubmed:authorpubmed-author:WalkR ARAlld:pubmed
pubmed-article:8085167pubmed:authorpubmed-author:ZhouZ NZNlld:pubmed
pubmed-article:8085167pubmed:authorpubmed-author:ZhuH YHYlld:pubmed
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pubmed-article:8085167pubmed:volume46lld:pubmed
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pubmed-article:8085167pubmed:pagination36-43lld:pubmed
pubmed-article:8085167pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8085167pubmed:articleTitle[The protective effect of MPEG-SOD on the function of left ventricle during acute hypoxia].lld:pubmed
pubmed-article:8085167pubmed:affiliationPhysiological Laboratory of Hypoxia, Shanghai Institute of Physiology, Chinese Academy of Sciences.lld:pubmed
pubmed-article:8085167pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8085167pubmed:publicationTypeEnglish Abstractlld:pubmed
pubmed-article:8085167pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed