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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1994-10-11
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pubmed:abstractText |
Using quantitative autoradiography we have investigated insulin-like growth factor (IGF)-I receptors in postmortem-obtained frontal cortex and white matter from 39 individuals without neurological disease, ranging in age from 0 to 95 years, and from 5 patients with Huntington's disease and 4 with Alzheimer's disease. IGF-I receptor densities in white matter were significantly higher in neonates than in adults; during adult life there was no further decline. The higher density of IGF-I receptors in white matter of neonates most likely reflects extensive formation of myelin. There was no significant decrease in IGF-I receptor densities in the cortical mantle with age, suggesting that the cells containing IGF-I receptors in frontal cortex are maintained during the entire life-span. There were no significant alterations in IGF-I receptor densities in frontal cortex and white matter from patients with Huntington's disease and Alzheimer's disease compared with controls from the same age groups.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8084545-Adolescent,
pubmed-meshheading:8084545-Adult,
pubmed-meshheading:8084545-Aged,
pubmed-meshheading:8084545-Aged, 80 and over,
pubmed-meshheading:8084545-Aging,
pubmed-meshheading:8084545-Alzheimer Disease,
pubmed-meshheading:8084545-Autoradiography,
pubmed-meshheading:8084545-Child,
pubmed-meshheading:8084545-Child, Preschool,
pubmed-meshheading:8084545-Female,
pubmed-meshheading:8084545-Humans,
pubmed-meshheading:8084545-Huntington Disease,
pubmed-meshheading:8084545-Infant,
pubmed-meshheading:8084545-Infant, Newborn,
pubmed-meshheading:8084545-Insulin-Like Growth Factor I,
pubmed-meshheading:8084545-Male,
pubmed-meshheading:8084545-Middle Aged,
pubmed-meshheading:8084545-Prefrontal Cortex,
pubmed-meshheading:8084545-Receptors, Somatomedin
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pubmed:year |
1994
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pubmed:articleTitle |
Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease.
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pubmed:affiliation |
Department of Neurology, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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