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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-10-13
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pubmed:abstractText |
Peritoneal macrophages undergoing apoptosis induced by Shigella flexneri infection release the inflammatory cytokine interleukin 1 (IL-1), but not IL-6 or tumor necrosis factor alpha (TNF alpha). Wild type shigella causes a very fast and significant release of IL-1 from prestimulated peritoneal macrophages, before the cell's integrity is compromised. Both IL-1 alpha and IL-1 beta are released, IL-1 beta in its mature processed form. IL-1 is released from presynthesized cytoplasmic pools. These results demonstrate that bacteria-induced apoptosis of macrophages may play an active role in vivo by releasing IL-1, which in turn mediates an early inflammatory response in epithelial tissues.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1431103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1544172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1614548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1835899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1924307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1939659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-1955773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2114366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2115174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2318968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2645214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2753407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2786911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-2787769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-3059992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-3282023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-6330537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8143119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8196540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8228619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8242741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8406793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8083373-8440434
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1328-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8083373-Animals,
pubmed-meshheading:8083373-Apoptosis,
pubmed-meshheading:8083373-Biological Assay,
pubmed-meshheading:8083373-Cells, Cultured,
pubmed-meshheading:8083373-Escherichia coli,
pubmed-meshheading:8083373-Interleukin-1,
pubmed-meshheading:8083373-Interleukin-6,
pubmed-meshheading:8083373-Lipopolysaccharides,
pubmed-meshheading:8083373-Macrophages, Peritoneal,
pubmed-meshheading:8083373-Male,
pubmed-meshheading:8083373-Mice,
pubmed-meshheading:8083373-Mice, Inbred C3H,
pubmed-meshheading:8083373-Shigella flexneri
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pubmed:year |
1994
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pubmed:articleTitle |
Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.
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pubmed:affiliation |
Unité de Pathogénie Microbienne Moléculaire, Institut National de la Santé et de la Recherche Médicale U389, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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