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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1994-10-10
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pubmed:abstractText |
GR79236 (N-[(1S,trans)-2-hydroxycyclopentyl]adenosine) is an orally active adenosine A1 receptor agonist, which decreases plasma non-esterified fatty acid levels in fasted rats. This study has quantified the effects of GR79236 on plasma non-esterified fatty acid levels, blood pressure and heart rate in conscious rats. Blood pressure and heart rate were continuously recorded in rats for 30 min before and 1 h after oral dosing with GR79236 (0.03-3 mg/kg) or vehicle. Plasma non-esterified fatty acid concentrations were determined in blood sampled before and 1 h after dosing. GR79236 produced dose-related reductions in plasma non-esterified fatty acid concentrations, with an almost maximal effect (63.2%) occurring after 1 mg/kg. This dose induced a small but significant decrease in heart rate (12.0%), and a non-significant decrease in mean blood pressure (6.3%). Thus, in the conscious rat, GR79236 can exert profound antilipolytic effects with minimal effects on blood pressure and heart rate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8082691-Adenosine,
pubmed-meshheading:8082691-Administration, Oral,
pubmed-meshheading:8082691-Animals,
pubmed-meshheading:8082691-Blood Pressure,
pubmed-meshheading:8082691-Dose-Response Relationship, Drug,
pubmed-meshheading:8082691-Esterification,
pubmed-meshheading:8082691-Fatty Acids,
pubmed-meshheading:8082691-Heart Rate,
pubmed-meshheading:8082691-Male,
pubmed-meshheading:8082691-Rats,
pubmed-meshheading:8082691-Receptors, Purinergic P1
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pubmed:year |
1994
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pubmed:articleTitle |
The effects of GR79236 on plasma fatty acid concentrations, heart rate and blood pressure in the conscious rat.
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pubmed:affiliation |
Department of Gastrointestinal, Glaxo Group Research, Ware, Hertfordshire, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study
|