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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-10-11
|
| pubmed:abstractText |
In the United States, the incidence of adenocarcinoma of the esophagus, including the esophagogastric (EG) junction, has been increasing rapidly over the past two decades. Except for an association with Barrett's esophagus, little is known about the etiology of these cancers. A population-based case-control interview study of 174 White men with adenocarcinoma of the esophagus and 750 controls living in three areas of the United States offered the opportunity to investigate the relationship of these cancers with smoking, alcohol drinking, socioeconomic factors, and history of ulcer. There were significantly elevated risks for men who smoked cigarettes (odds ratio [OR] = 2.1) or drank liquor (OR = 1.6). For both cigarette smoking and liquor drinking, there were significant dose gradients with amount consumed. No reduction in risk was observed following smoking cessation. Subjects who switched from nonfilter to filter cigarettes experienced half the risk of those who only smoked nonfilter cigarettes. Inverse risk gradients were seen with increasing recent annual income, with the highest risk (OR = 3.4) for the lowest category. The risk for a history of ulcer (OR = 1.7), especially of the duodenum (OR = 2.2), was also significantly elevated. These data suggest that tobacco and alcohol may be etiologic factors for adenocarcinoma of the esophagus and EG junction, but these factors do not appear to explain the rapid rise in incidence of these tumors. The associations with low social class and history of ulcer need to be explored in greater detail along with other factors that may account for the temporal trends in esophageal adenocarcinomas.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0957-5243
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
333-40
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8080945-Adenocarcinoma,
pubmed-meshheading:8080945-Adult,
pubmed-meshheading:8080945-Aged,
pubmed-meshheading:8080945-Alcohol Drinking,
pubmed-meshheading:8080945-Alcoholic Beverages,
pubmed-meshheading:8080945-Case-Control Studies,
pubmed-meshheading:8080945-Duodenal Ulcer,
pubmed-meshheading:8080945-Educational Status,
pubmed-meshheading:8080945-Esophageal Neoplasms,
pubmed-meshheading:8080945-Esophagogastric Junction,
pubmed-meshheading:8080945-European Continental Ancestry Group,
pubmed-meshheading:8080945-Humans,
pubmed-meshheading:8080945-Income,
pubmed-meshheading:8080945-Male,
pubmed-meshheading:8080945-Middle Aged,
pubmed-meshheading:8080945-Registries,
pubmed-meshheading:8080945-Risk Factors,
pubmed-meshheading:8080945-Smoking,
pubmed-meshheading:8080945-Smoking Cessation,
pubmed-meshheading:8080945-Socioeconomic Factors,
pubmed-meshheading:8080945-Stomach Ulcer,
pubmed-meshheading:8080945-United States
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Adenocarcinoma of the esophagus and esophagogastric junction in white men in the United States: alcohol, tobacco, and socioeconomic factors.
|
| pubmed:affiliation |
Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|