Linked Life Data

808060

Source:http://linkedlifedata.com/resource/pubmed/id/808060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-11-7
pubmed:abstractText
Incubation of the synthetic estrogen 17alpha-ethinyl-estradiol-3-methylether (mestranol) with cultures of Penicillium chrysogenum gave 6alpha-hydroxy-17alpha-ethinylestradiol-3-methylether and 6beta-hydroxy-17alpha-ethinylestradiol-3-methylether. The corresponding 3-demethylated compound, 17alpha-ethinylestradiol, gave the 6alpha- and 6beta-hydroxy derivatives in lower yields. If the 6-hydroxy compounds were incubated, they were partially isomerized to a mixture of the 6alpha- and 6beta-hydroxy compounds. Estradiol, estrone and the corresponding methylethers were not hydroxylated. By incubation with cultures of Streptomyces olivaceus, estradiol, estrone and the corresponding methylethers were hydroxylated to 16alpha-hydroxy derivatives. 17alpha-Ethinyl compounds were not hydroxylated. 17alpha-Azidomethyl estradiol gave 17alpha-hydroxymethyl estradiol. Structures were established by chromatographical comparison and by IR and NMR spectra. Relations between metabolism of estratrienes by the mentioned microorganisms and the mammalian metabolism are discussed
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5318
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
[Microbial hydroxylation of estratrienes].
pubmed:publicationType
Journal Article, English Abstract