Linked Life Data

8078026

Source:http://linkedlifedata.com/resource/pubmed/id/8078026

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-10-6
pubmed:abstractText
Sepsis is associated with a generalised membrane dysfunction leading to an increase in intracellular sodium, chloride, and water. The decrease in extracellular water is thought to act as a nonosmotic stimulus to the secretion of antidiuretic hormone. The resultant hyponatraemia is associated with increased surgical morbidity and mortality. Treatment aimed at improving intracellular electrolytes may improve surgical morbidity and mortality. An animal model of peritonitis was used to evaluate the effect of pentoxifylline. Previously, this dimethyl xanthine derivative was shown to stabilise the cell membrane. Administration of pentoxifylline significantly lowered intracellular sodium and chloride, particularly when given after caecal ligation and puncture. This may have clinical implications in the treatment and prevention of hyponatraemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3468
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
801-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Pentoxifylline improves intracellular electrolytes in sepsis.
pubmed:affiliation
Royal Belfast Hospital for Sick Children, Northern Ireland.
pubmed:publicationType
Journal Article