Linked Life Data

8077990

Source:http://linkedlifedata.com/resource/pubmed/id/8077990

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-10-4
pubmed:abstractText
Levofloxacin, the S-(-)-isomer of ofloxacin, was compared to ofloxacin and ciprofloxacin against > 6000 recent clinical isolates of Gram-positive and Gram-negative bacteria from six different countries. This international multicenter study demonstrated a high level of antibacterial activity of levofloxacin against all the members of Enterobacteriaceae [minimum inhibitory concentration (MIC)50s, < or = 0.03 to 0.12 mg/L] except Providencia rettgeri (MIC50, 2 mg/L), and Providencia stuartii (MIC50, 1 mg/L). Oxacillin-susceptible staphylococci (MIC50s, 0.12 to 0.25 mg/L), enterococci (MIC50s, 0.5 to 2 mg/L), and streptococci (MIC50s, 0.5 mg/L) were also susceptible to levofloxacin, but most isolates of oxacillin-resistant staphylococci had MICs of > or = 4 mg/L. Levofloxacin was also active against non-enteric Gram-negative bacilli, including Acinetobacter species (MIC50s, < or = 0.03 to 1 mg/L), Pseudomonas species (MIC50s, 0.5 to 1 mg/L) and Xanthomonas maltophilia (MIC50, 0.5 mg/L). Overall, levofloxacin inhibited 50% and 90% of all the tested strains at the concentrations of 0.12 and 4 mg/L, respectively. The activity of levofloxacin was generally two-fold greater than ofloxacin and equal to or slightly less potent than ciprofloxacin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1120-009X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-91
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Levofloxacin in vitro activity: results from an international comparative study with ofloxacin and ciprofloxacin.
pubmed:affiliation
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Multicenter Study