|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1994-10-6
|
|
pubmed:abstractText |
The proliferative response of lymphocytes induced by a new streptococcal mitogenic factor (MF) and the streptococcal pyrogenic exotoxins (Spe) A and B was determined in sera from 6 healthy persons. Responses were compared to those obtained from reference serum that lacked mitogen-specific ELISA antibodies. The sera showed individual variations in the levels of MF- and Spe-specific antibodies, as determined by ELISA. The experiments showed that most human sera, which contained mitogen-specific antibodies, could neutralize the mitogenicity of the proteins. However, there were sera that contained mitogen-specific antibodies but that did not inhibit the toxin-induced proliferation. Thus, the ELISA antibody titer did not always equal the neutralizing capacity. Sera from 27 patients with group A streptococcal bacteremia had significantly lower neutralizing ability against MF and SpeB than did sera from 25 uncomplicated tonsillitis cases.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SpeA protein, Streptococcus pyogenes,
http://linkedlifedata.com/resource/pubmed/chemical/erythrogenic toxin,
http://linkedlifedata.com/resource/pubmed/chemical/mitogenic factor, Streptococcus
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
170
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
585-91
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8077715-Adult,
pubmed-meshheading:8077715-Antibodies, Bacterial,
pubmed-meshheading:8077715-Antibody Formation,
pubmed-meshheading:8077715-Bacterial Proteins,
pubmed-meshheading:8077715-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8077715-Exotoxins,
pubmed-meshheading:8077715-Female,
pubmed-meshheading:8077715-Humans,
pubmed-meshheading:8077715-Immunoglobulin G,
pubmed-meshheading:8077715-Lymphocyte Activation,
pubmed-meshheading:8077715-Lymphocytes,
pubmed-meshheading:8077715-Membrane Proteins,
pubmed-meshheading:8077715-Neutralization Tests,
pubmed-meshheading:8077715-Pregnancy,
pubmed-meshheading:8077715-Pregnancy Complications, Infectious,
pubmed-meshheading:8077715-Pregnancy Trimester, First,
pubmed-meshheading:8077715-Reference Values,
pubmed-meshheading:8077715-Streptococcal Infections,
pubmed-meshheading:8077715-Streptococcus pyogenes
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Relation between low capacity of human sera to inhibit streptococcal mitogens and serious manifestation of disease.
|
|
pubmed:affiliation |
Department of Clinical Bacteriology, University of Umeå, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
