Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1975-10-28
|
| pubmed:abstractText |
Spleen cells from normal DBA/2 mice pretreated with a soluble factor from mastocytoma cells or from ascitic fluid of mastocytoma-bearing mice were markedly impaired in terms of antibody formation to SRBC in vitro. Such immunosuppression by mastocytoma homogenates or ascitic fluid was reversed when syngeneic T cells activated to SRBC were added to the cultures, but not when peritoneal exudate cells or anti-theta-treated normal splenocytes were used. Activated T cells, as well as normal B lymphocytes prepared from spleens of lethally irradiated mice reconstituted with bone marrow cells, were less sensitive to the immunosuppressive factor than non-activated T cells. The ability of educated T cells to restore immunocompetence of suppressed spleen cells in vitro suggests that the target of the immunosuppressive factor from mastocytoma cells may be non-activated T cells, especially those involved in T cell helper function.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
115
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
382-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:807635-Animals,
pubmed-meshheading:807635-Antibody Formation,
pubmed-meshheading:807635-Antibody-Producing Cells,
pubmed-meshheading:807635-Antigens,
pubmed-meshheading:807635-Ascitic Fluid,
pubmed-meshheading:807635-B-Lymphocytes,
pubmed-meshheading:807635-Cells, Cultured,
pubmed-meshheading:807635-Erythrocytes,
pubmed-meshheading:807635-Female,
pubmed-meshheading:807635-Hemolytic Plaque Technique,
pubmed-meshheading:807635-Immunization,
pubmed-meshheading:807635-Immunosuppression,
pubmed-meshheading:807635-Mast-Cell Sarcoma,
pubmed-meshheading:807635-Mice,
pubmed-meshheading:807635-Mice, Inbred DBA,
pubmed-meshheading:807635-Peritoneum,
pubmed-meshheading:807635-Radiation Effects,
pubmed-meshheading:807635-Sheep,
pubmed-meshheading:807635-Spleen,
pubmed-meshheading:807635-T-Lymphocytes,
pubmed-meshheading:807635-Thymus Gland
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Restoration of in vitro immune responsiveness of mastocytoma-suppressed splenocytes by activated T cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|