rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9
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pubmed:dateCreated |
1994-10-6
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pubmed:abstractText |
Cadherin cell-cell adhesion molecules are associated with cytoskeletal proteins, including alpha and beta catenin, and plakoglobin. This cadherin-catenin complex plays an indispensable role in construction of ordered multicellular structures such as polarized epithelium. alpha-catenin is crucial for the cell binding function of cadherins; without it, cells cannot use the cadherin adhesion system for their adhesion. beta-catenin and plakoglobin possibly play more regulatory roles, as it was shown that their tyrosine phosphorylation correlated with modified cadherin activities. The expression of some cadherin-associated proteins is controlled by the wingless/Wnt-1 signal in embryos. These regulatory mechanisms of cadherin function and expression may be involved in dynamic control of cell-cell contacts during morphogenesis, and even in certain processes of cell growth and differentiation.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Desmoplakins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/alpha Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0764-4469
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
316
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8076212-Animals,
pubmed-meshheading:8076212-Cadherins,
pubmed-meshheading:8076212-Cell Adhesion,
pubmed-meshheading:8076212-Cell Adhesion Molecules,
pubmed-meshheading:8076212-Cytoskeletal Proteins,
pubmed-meshheading:8076212-Desmoplakins,
pubmed-meshheading:8076212-Epithelium,
pubmed-meshheading:8076212-Gene Expression Regulation,
pubmed-meshheading:8076212-Humans,
pubmed-meshheading:8076212-Morphogenesis,
pubmed-meshheading:8076212-Trans-Activators,
pubmed-meshheading:8076212-alpha Catenin,
pubmed-meshheading:8076212-beta Catenin,
pubmed-meshheading:8076212-gamma Catenin
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pubmed:year |
1993
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pubmed:articleTitle |
Dynamic control of cell-cell adhesion for multicellular organization.
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pubmed:affiliation |
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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