Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-10-5
pubmed:abstractText
1. Electrophysiological recordings from rat ventromedial hypothalamus (VMH) in vitro have been used to compare the effects of novel chemical entities on CCKB receptor activation in the rat central nervous system. 2. Twenty compounds from three different chemical series were evaluated for their ability to reduce pentagastrin-induced increases in action potential firing rate. 3. All twenty compounds studies were found to be CCKB antagonists, with equilibrium constants spanning a concentration-range of several orders of magnitude. The rank order for their ability to block pentagastrin responses correlated well with values obtained for their relative affinities for the mouse cortex CCKB binding site. 4. It is concluded that the VMH preparation provides a good functional correlate to binding assays in the rodent central nervous system for a structurally diverse series of CCKB antagonists.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-1698290, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-1881532, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-1881533, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-1975695, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-2180549, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-2625140, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-2721567, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-284371, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-2848124, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-3014519, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-3014520, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-3401640, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-4745816, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-6294831, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-63918, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-6546809, http://linkedlifedata.com/resource/pubmed/commentcorrection/8075886-7684452
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
666-70
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Evaluation of a series of novel CCKB antagonists using a functional assay in the rat central nervous system.
pubmed:affiliation
Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge.
pubmed:publicationType
Journal Article, In Vitro