Linked Life Data

8075531

Source:http://linkedlifedata.com/resource/pubmed/id/8075531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-10-3
pubmed:abstractText
Studies have shown the existence of minor developmental cortical malformations, including microgyria, in the brains of dyslexics. Concomitant studies have shown that language-impaired individuals exhibit severe deficits in the discrimination of rapidly presented auditory stimuli, including phonological and nonverbal stimuli (i.e., sequential tones). In an effort to relate these results, male rats with neonatally induced microgyria were tested in an operant paradigm for auditory discrimination of stimuli consisting of two sequential tones. Subjects were shaped to perform a go/no-go target identification, using water reinforcement. Stimuli were reduced in duration from 540 to 249 msec across 24 d of testing. Results showed that all subjects were able to discriminate at longer stimulus durations. However, bilaterally lesioned subjects showed specific impairment at stimulus durations of 332 msec or less, and were significantly depressed in comparison to shams. Right- and left-lesioned subjects were significantly depressed in comparison to shams at the shortest duration (249 msec). These results suggest a possible link between the neuropathologic anomalies and the auditory temporal processing deficits reported for language-impaired individuals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1047-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-70
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Induced microgyria and auditory temporal processing in rats: a model for language impairment?
pubmed:affiliation
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't