Linked Life Data

80754

Source:http://linkedlifedata.com/resource/pubmed/id/80754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1978-12-2
pubmed:abstractText
5-Aza-2'-deoxycytidine-3H administered i. p. to mice is preferentially incorporated into nucleic acids in the spleen and thymus. The labeling of the spleen is maximal during first hours after drug administration and decreases rapidly thereafter. Following administration, 5-aza-2'-deoxycytidine is metabolized giving rise to several new compounds. The incorporation of 5-aza-2'-deoxycytidine is blocked by the simultaneously administered deoxycytidine to a lesser degree than that of deoxycytidine by the analogue. Maximal inhibition of deoxycytidine incorporation by the drug was observed in the spleen; the incorporation of thymidine under similar conditions was diminished only about 20%. However, pretreatment of the animals with the analogue resulted in a strong inhibition of thymidine incorporation (about 80%) both in the spleen and the thymus. Simultaneously the activity of thymidine and thymidylate kinases in cell-free spleen extracts was markedly depressed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-93
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Effects of 5-aza-2'-deoxycytidine on DNA synthesis in mouse lymphatic tissues.
pubmed:publicationType
Journal Article