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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1994-9-27
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pubmed:abstractText |
Serum obtained from an infertile subject possessed antibodies that interacted with a human sperm glycoprotein with an estimated M(r) of 17,550 and pI of 5.65 containing 17.7% neutral hexoses and designated as the BS-17 component. Polyclonal antibodies raised against the BS-17 antigen blocked the capacity of human sperm to fertilize zona-free hamster ova in vitro; however, the antibodies did not influence the binding of human sperm to zone-free ova or alter the motility of human sperm. The antibodies inhibited the capacity of mouse sperm to fertilize ova upon in vivo insemination. The BS-17 antigen was detected in human, rat, mouse, rabbit, and hamster sperm by an immunocytochemical method, using polyclonal anti-BS-17 antibodies. Intense staining occurred over the surface of the acrosomal region of all mammalian sperm. The results suggest that the production of anti-BS-17 antibodies contribute to infertility by preventing the capacitation of sperm and/or by blocking the ability of capacitated sperm to fertilize the egg.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0148-5016
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8074581-Animals,
pubmed-meshheading:8074581-Antibodies,
pubmed-meshheading:8074581-Antigens,
pubmed-meshheading:8074581-Cricetinae,
pubmed-meshheading:8074581-Female,
pubmed-meshheading:8074581-Humans,
pubmed-meshheading:8074581-Infertility, Female,
pubmed-meshheading:8074581-Male,
pubmed-meshheading:8074581-Mice,
pubmed-meshheading:8074581-Molecular Weight,
pubmed-meshheading:8074581-Proteins,
pubmed-meshheading:8074581-Sperm Capacitation,
pubmed-meshheading:8074581-Sperm Motility,
pubmed-meshheading:8074581-Sperm-Ovum Interactions,
pubmed-meshheading:8074581-Spermatozoa
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pubmed:articleTitle |
Fertility studies with antisperm antibodies.
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pubmed:affiliation |
Chinese Academy of Medical Sciences, Institute of Basic Medical Sciences, Beijing.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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