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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-9-29
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pubmed:abstractText |
We evaluated the effect of ornithine ketoglutarate (OKG) in reversing abnormal growth in six prepubertal children receiving total parenteral nutrition (TPN) for 5-10 y. They were 1-4 SDs below their expected 50th percentile for height. The energy and nitrogen intakes were unchanged from 8 mo before the beginning of the study until its completion. Two consecutive periods of 5 mo each were studied. OKG (15 g) was added to the parenteral solution during the first period (OKG+) but not during the second period (OKG-). Height velocity (HV) increased (P < 0.05) from a median of 3.8 cm/y to 6.45 cm/y (range 1.8-6.7) during the OKG+ period, and decreased (P < 0.05) to a median of 3.65 cm/y in the OKG- period. Plasma concentrations of insulin-like growth factor 1 (IGF1), glutamine, and glutamate increased (P < 0.05) during the OKG+ period. Variations of IGF1 concentrations correlated with HV variations (r = 0.82, P < 0.005) during both periods. This study demonstrates that OKG is associated with statural growth acceleration and increased IGF1 concentrations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Ornithine,
http://linkedlifedata.com/resource/pubmed/chemical/Prealbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Retinol-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinol-Binding Proteins, Plasma,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/ornithine alpha-ketoglutarate
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9165
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
408-13
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8074074-Adolescent,
pubmed-meshheading:8074074-Amino Acids,
pubmed-meshheading:8074074-Anthropometry,
pubmed-meshheading:8074074-Body Height,
pubmed-meshheading:8074074-Child,
pubmed-meshheading:8074074-Female,
pubmed-meshheading:8074074-Glutamates,
pubmed-meshheading:8074074-Glutamine,
pubmed-meshheading:8074074-Growth Disorders,
pubmed-meshheading:8074074-Humans,
pubmed-meshheading:8074074-Insulin-Like Growth Factor I,
pubmed-meshheading:8074074-Male,
pubmed-meshheading:8074074-Ornithine,
pubmed-meshheading:8074074-Parenteral Nutrition, Total,
pubmed-meshheading:8074074-Prealbumin,
pubmed-meshheading:8074074-Retinol-Binding Proteins,
pubmed-meshheading:8074074-Retinol-Binding Proteins, Plasma,
pubmed-meshheading:8074074-Serum Albumin,
pubmed-meshheading:8074074-Transferrin
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pubmed:year |
1994
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pubmed:articleTitle |
Growth retardation in children receiving long-term total parenteral nutrition: effects of ornithine alpha-ketoglutarate.
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pubmed:affiliation |
Department of Pediatrics, Maimonides Medical Center, Brooklyn, NY.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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