Linked Life Data

8071939

Source:http://linkedlifedata.com/resource/pubmed/id/8071939

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1994-9-23
pubmed:abstractText
1,2-Bis(sulfonyl)-1-alkylhydrazines are highly active experimental antineoplastic agents which decompose with first-order kinetics in neutral aqueous solutions. These agents generate approximately 2 mol of the corresponding sulfinate, 1 mol of nitrogen, and 1 mol of the appropriate alcohol, produced as a consequence of the alkylation of water. Increasing the leaving-group ability of the sulfonyl moiety on N-1 shortens the half-life, while the converse happens with N-2 substitutions. Linear Hammett relationships are found for both types of substitutions. The predictable kinetics of decomposition makes these agents potential candidates for use in regional chemotherapy, where compounds with tunable short half-lives may offer some advantage. Prodrugs of extremely short-lived derivatives of this class may also have utility as targeted alkylating agents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2912-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Studies on the mechanism of decomposition and structural factors affecting the aqueous stability of 1,2-bis(sulfonyl)-1-alkylhydrazines.
pubmed:affiliation
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.