Linked Life Data

8071670

Source:http://linkedlifedata.com/resource/pubmed/id/8071670

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-9-23
pubmed:abstractText
The in-vitro post-antibiotic effect (PAE) was determined for two newer beta-lactams, FK-037 (a cephalosporin) and biapenem (a carbapenem). Our PAE results for these drugs were consistent with what has been reported previously for similar beta-lactams, e.g. Gram-positive organisms had measurable effects (0.4-2.2 hours), while Gram-negatives had variable results (0.0 to 1.4 hours). Even though the PAE test conditions generally coincided with achievable clinical levels for most organisms tested (< or = 4 mg/L for biapenem and < or = 8 mg/L for FK-037), the marginal or species dependent, short PAE values support the selection of multiple daily doses (two-to-four) based on conventional pharmacokinetic parameters such as the Cmax, AUC, and serum elimination half-life.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1120-009X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-4
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Post-antibiotic effect of FK-037 and biapenem tested against five bacterial species.
pubmed:affiliation
Medical Microbiology Division, University of Iowa College of Medicine, Iowa City 52242.
pubmed:publicationType
Journal Article