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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1994-9-27
|
| pubmed:abstractText |
Based on our studies on the enzymatic modifications of arbekacin by methicillin-resistant Staphylococcus aureus (MRSA), replacement of the 2''-hydroxyl group by an amino group in arbekacin was designed to synthesize derivatives that would be active against MRSA. 2''-Amino-2''-deoxyarbekacin and five analogs were synthesized starting from dibekacin. Among them, 2''-amino-2''-deoxyarbekacin and the 5-epiamino analog showed excellent antibacterial activities against not only MRSA but also Gram-negative bacteria including Pseudomonas, and lower toxicities than arbekacin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
821-32
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:8071128-Carbohydrate Sequence,
pubmed-meshheading:8071128-Dibekacin,
pubmed-meshheading:8071128-Gram-Negative Bacteria,
pubmed-meshheading:8071128-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8071128-Methicillin Resistance,
pubmed-meshheading:8071128-Microbial Sensitivity Tests,
pubmed-meshheading:8071128-Molecular Sequence Data,
pubmed-meshheading:8071128-Staphylococcus,
pubmed-meshheading:8071128-Staphylococcus aureus,
pubmed-meshheading:8071128-Structure-Activity Relationship
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Synthesis of 2''-amino-2''-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus.
|
| pubmed:affiliation |
Institute of Microbial Chemistry, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|