| pubmed-article:8070663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C1705920 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:8070663 | lifeskim:mentions | umls-concept:C0682002 | lld:lifeskim |
| pubmed-article:8070663 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8070663 | pubmed:dateCreated | 1994-9-27 | lld:pubmed |
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| pubmed-article:8070663 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8070663 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8070663 | pubmed:abstractText | Substantial insights into basic strategies for embryonic body patterning have been obtained from genetic analyses of Drosophila melanogaster. This knowledge has been used in evolutionary comparisons to ask if genes and functions are conserved. To begin to ask how highly conserved are the mechanisms of mRNA localization, a process crucial to Drosophila body patterning, we have focused on the localization of bcd mRNA to the anterior pole of the embryo. Here we consider two components involved in that process: the exuperantia (exu) gene, required for an early step in localization; and the cis-acting signal that directs bcd mRNA localization. First, we use the cloned D. melanogaster exu gene to identify the exu genes from Drosophila virilis and Drosophila pseudoobscura and to isolate them for comparisons at the structural and functional levels. Surprisingly, D. pseudoobscura has two closely related exu genes, while D. melanogaster and D. virilis have only one each. When expressed in D. melanogaster ovaries, the D. virilis exu gene and one of the D. pseudoobscura exu genes can substitute for the endogenous exu gene in supporting localization of bcd mRNA, demonstrating that function is conserved. Second, we reevaluate the ability of the D. pseudoobscura bcd mRNA localization signal to function in D. melanogaster. In contrast to a previous report, we find that function is retained. Thus, among these Drosophila species there is substantial conservation of components acting in mRNA localization, and presumably the mechanisms underlying this process. | lld:pubmed |
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| pubmed-article:8070663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8070663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8070663 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8070663 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8070663 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8070663 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:8070663 | pubmed:author | pubmed-author:KilpatrickMM | lld:pubmed |
| pubmed-article:8070663 | pubmed:author | pubmed-author:KernGG | lld:pubmed |
| pubmed-article:8070663 | pubmed:author | pubmed-author:MacdonaldP... | lld:pubmed |
| pubmed-article:8070663 | pubmed:author | pubmed-author:GEED WDW | lld:pubmed |
| pubmed-article:8070663 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8070663 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:8070663 | pubmed:geneSymbol | exu | lld:pubmed |
| pubmed-article:8070663 | pubmed:geneSymbol | exu1 | lld:pubmed |
| pubmed-article:8070663 | pubmed:geneSymbol | exu2 | lld:pubmed |
| pubmed-article:8070663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8070663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8070663 | pubmed:pagination | 521-30 | lld:pubmed |
| pubmed-article:8070663 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8070663 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8070663 | pubmed:articleTitle | Components acting in localization of bicoid mRNA are conserved among Drosophila species. | lld:pubmed |
| pubmed-article:8070663 | pubmed:affiliation | Department of Biological Sciences, Stanford University, California 94305-5020. | lld:pubmed |
| pubmed-article:8070663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8070663 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8070663 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8070663 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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