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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-9-29
|
| pubmed:abstractText |
Globoid cell leukodystrophy (GLD) is a severe genetic demyelinating disorder with an increased number of Ia (immune response antigen) positive brain microglia/macrophages. To assess the role of aberrant Ia expression in the central nervous system (CNS), twitcher mice, which represent the murine model for GLD, were mated with Ia- transgenic mice. Compared with the Ia+ controls, Ia- twitcher mice showed a profound reduction in the severity of demyelinating lesions correlated with significantly fewer microglia/macrophages. Most importantly, Ia- twitcher mice showed significantly reduced twitching compared with ia+ twitcher mice. In contrast with experimental allergic encephalomyelitis (EAE), there was no significant amount of inflammatory T cell infiltrates, implying that T cells may not play a predominant role in this disease. These findings may have broad therapeutic implications for Alzheimer's disease, Parkinson's disease, and Huntington's disease, which display enhanced Ia expression in the CNS without obvious T cell infiltrates.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
645-56
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8069913-Animals,
pubmed-meshheading:8069913-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:8069913-Bone Marrow Cells,
pubmed-meshheading:8069913-Central Nervous System,
pubmed-meshheading:8069913-Crosses, Genetic,
pubmed-meshheading:8069913-Disease Models, Animal,
pubmed-meshheading:8069913-Female,
pubmed-meshheading:8069913-Galactosylceramidase,
pubmed-meshheading:8069913-Genes, MHC Class II,
pubmed-meshheading:8069913-Histocompatibility Antigens Class II,
pubmed-meshheading:8069913-Leukodystrophy, Globoid Cell,
pubmed-meshheading:8069913-Macrophages,
pubmed-meshheading:8069913-Male,
pubmed-meshheading:8069913-Mice,
pubmed-meshheading:8069913-Mice, Neurologic Mutants,
pubmed-meshheading:8069913-Mice, Transgenic,
pubmed-meshheading:8069913-Microglia,
pubmed-meshheading:8069913-Mutation,
pubmed-meshheading:8069913-Spleen,
pubmed-meshheading:8069913-T-Lymphocyte Subsets
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy.
|
| pubmed:affiliation |
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|