Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-9-28
|
| pubmed:abstractText |
Interleukin-1 (IL-1) has been shown to ameliorate the hematopoietic toxicities of antitumor chemotherapeutic agents in both mice and humans. However, IL-1 toxicity in humans is considerable and is similar to the systemic inflammatory toxicities induced by IL-3, IL-6, and other cytokines with pleiotropic biologic activities, eg, fever, nausea, malaise, and hypotension. We hypothesized that corticosteroids may reduce IL-1 toxicity without reducing IL-1 hematopoietic effects in vivo. C3H/HeJ mice (female, 6 weeks) were treated for 7 days subcutaneously with cortisone acetate (CA), (0.1, 0.25, or 0.5 mg/d/mouse), intraperitoneally with IL-1 (1 or 2 micrograms/d/mouse), or both. As expected, IL-1 increased white blood cell counts, splenic granulocyte-macrophage colony-forming units, and spleen cell number, and protected mice from lethal doses of carboplatin (200 mg/kg; Paraplatin, Bristol Laboratories, Evansville, IN) administered the day after completion of the 7 days of IL-1 administration. CA did not significantly block the hematopoietic effects of IL-1 or the ability of IL-1 to protect mice from the hematopoietic toxicity of carboplatin. IL-1 administered to mice at 8 micrograms/d/mouse for 5 days induced decreased activity, roughening of hair, diarrhea, pancytopenia, multiple metabolic abnormalities, and death in 60% of mice. IL-1 at the therapeutic doses (0.5 to 2 micrograms/d) was not toxic. CA in a dose-dependent manner blocked all of the above mentioned toxicities when administered 24 hours and 30 minutes before each IL-1 injection. CA also decreased IL-1-induced increase in plasma tumor necrosis factor levels at the time point examined.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carboplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Cortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/cortisone acetate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1457-63
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8068940-Animals,
pubmed-meshheading:8068940-Bone Marrow,
pubmed-meshheading:8068940-Bone Marrow Cells,
pubmed-meshheading:8068940-Carboplatin,
pubmed-meshheading:8068940-Colony-Forming Units Assay,
pubmed-meshheading:8068940-Cortisone,
pubmed-meshheading:8068940-Dose-Response Relationship, Drug,
pubmed-meshheading:8068940-Female,
pubmed-meshheading:8068940-Hematopoiesis,
pubmed-meshheading:8068940-Hematopoietic Stem Cells,
pubmed-meshheading:8068940-Humans,
pubmed-meshheading:8068940-Injections, Intraperitoneal,
pubmed-meshheading:8068940-Injections, Subcutaneous,
pubmed-meshheading:8068940-Interleukin-1,
pubmed-meshheading:8068940-Leukocyte Count,
pubmed-meshheading:8068940-Mice,
pubmed-meshheading:8068940-Mice, Inbred C3H,
pubmed-meshheading:8068940-Monocytes,
pubmed-meshheading:8068940-S Phase,
pubmed-meshheading:8068940-Spleen,
pubmed-meshheading:8068940-Time Factors,
pubmed-meshheading:8068940-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Corticosteroid modulation of interleukin-1 hematopoietic effects and toxicity in a murine system.
|
| pubmed:affiliation |
Department of Medicine, Scott & White Clinic, Temple, TX 76508.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|