Linked Life Data

8068894

Source:http://linkedlifedata.com/resource/pubmed/id/8068894

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-9-27
pubmed:abstractText
Early milk of rats contains high concentrations of many hormones and growth factors. Studies were undertaken to evaluate the physiological effects of early rat milk infranatant, insulin-like growth factors (IGFs) and epidermal growth factor (EGF) upon the growth and development of intestinal tissues in newborn rat pups. In one study, pups were artificially reared for 3 days (d2-d5) then fostered back to the dam. Treatment groups were mother fed controls (MF), artificially reared pups fed rat milk replacer (RMR) or RMR with infranatant from rat milk (r-Infra) or bovine milk (b-Infra). After 8 days, survival in the MF and RMR + r-Infra groups was 100% while survival in the RMR + b-Infra and RMR groups were 50 and 30% respectively. In additional experiments, pups were separated from the dam at birth (no suckling) and sacrificed after 2 days of artificial feeding. Treatments included RMR, RMR + r-Infra, and RMR + long Arg-IGF-I + EGF and were compared to MF control. Histological and autoradiographical evaluation of the intestines from MF controls showed advanced differentiation characterized by proliferative cell populations which were restrictively localized to the basal areas of the mucosa. In contrast, intestinal proliferation in the RMR group was diffusely distributed along both the lower regions of the villi and the crypts. Pups fed RMR + r-Infra exhibited intermediate morphology. Pups artificially fed RMR + long Arg-IGF-I + EGF produced a dramatic establishment of an active crypt-villus axis within two days of feeding.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1210-0668
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Milk-borne factors affect survival, intestinal growth and development in newborn rats.
pubmed:affiliation
Department of Dairy and Animal Science, Pennsylvania State University, University Park.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't