Linked Life Data

8068461

Source:http://linkedlifedata.com/resource/pubmed/id/8068461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-29
pubmed:abstractText
3H-labeled chemically modified, non-antimicrobial tetracycline (4-de-dimethyl-aminotetracycline; CMT) was injected intraperitoneally into neonatal rats and the animals killed at 20 min, 2 or 4 h after isotope injection. The binding of 3H-CMT in the calvariae was localized by light and electron microscopic autoradiography. At 20 min after injection, a high level of bound 3H-CMT was localized in the cells of the periosteum including the osteoblasts and preosteoblasts. The newly formed bone matrix was also heavily labeled by silver grains. At the ultrastructural level, many silver grains appeared over the cytoplasm of osteoblasts and preosteoblasts, particularly along the plasma membranes, in the periosteum. At 2 and/or 4 h after isotope injection, the number of silver grains over the cells was markedly reduced by that over the bone matrix appeared unchanged. These results indicate that, in addition to the mineral phase of bone, CMT directly binds to (or is taken up by) osteogenic cells and is then rapidly metabolized by these cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Bone cells and matrix bind chemically modified non-antimicrobial tetracycline.
pubmed:affiliation
Second Department of Oral Anatomy, School of Dentistry, Showa University, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.