8067737

Source:http://linkedlifedata.com/resource/pubmed/id/8067737

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0026336, umls-concept:C0033809, umls-concept:C0081786, umls-concept:C0681842, umls-concept:C0949285
pubmed:issue	5
pubmed:dateCreated	1994-9-19
pubmed:abstractText	A computer model of biofilm dynamics was adapted to incorporate the activity of an antimicrobial agent on bacterial biofilm. The model was used to evaluate the plausibility of two mechanisms of biofilm antibiotic resistance by qualitative comparison with data from a well-characterized experimental system (H. Anwar, J. L. Strap, and J. W. Costerton, Antimicrob. Agents Chemother. 36:1208-1214, 1992). The two mechanisms involved either depletion of the antibiotic by reaction with biomass or physiological resistance due to reduced bacterial growth rates in the biofilm. Both mechanisms predicted the experimentally observed resistance of 7-day-old Pseudomonas aeruginosa biofilms compared with that of 2-day-old ones. A version of the model that incorporated growth rate-dependent killing predicted reduced susceptibility of thicker biofilms because oxygen was exhausted within these biofilms, leading to very slow growth in part of the biofilm. A version of the model that incorporated a destructive reaction of the antibiotic with biomass likewise accounted for the relative resistance of thicker biofilms. Resistance in this latter case was due to depletion of the antibiotic in the bulk fluid rather than development of a gradient in the antibiotic concentration within the biofilm. The modeling results predicted differences between the two cases, such as in the survival profiles within the biofilm, that could permit these resistance mechanisms to be experimentally distinguished.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-1317406, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-1416820, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-1422883, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-1622256, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-1763187, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-2190969, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-2291653, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-2516117, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-3072331, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-3318676, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067737-3534137
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0066-4804
pubmed:author	pubmed-author:StewartP SPS
pubmed:issnType	Print
pubmed:volume	38
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1052-8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:8067737-Anti-Bacterial Agents, pubmed-meshheading:8067737-Diffusion, pubmed-meshheading:8067737-Drug Resistance, Microbial, pubmed-meshheading:8067737-Kinetics, pubmed-meshheading:8067737-Models, Biological, pubmed-meshheading:8067737-Pseudomonas aeruginosa
pubmed:year	1994
pubmed:articleTitle	Biofilm accumulation model that predicts antibiotic resistance of Pseudomonas aeruginosa biofilms.
pubmed:affiliation	Center for Biofilm Engineering, Montana State University, Bozeman 59717-0398.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't