Linked Life Data

8067697

Source:http://linkedlifedata.com/resource/pubmed/id/8067697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3B
pubmed:dateCreated
1994-9-22
pubmed:abstractText
Biopsies from 34 patients with cancer of the head, neck or esophagus, 2 laryngeal papillomas, and 2 normal tonsils were analysed for human papillomavirus (HPV), Epstein Barr virus (EBV) genomes and mutated or elevated levels of p53. In 4 biopsies p53 was also analysed by DNA sequencing. HPV type 31 was found in one laryngeal cancer with normal p53 and HPV type 16 in two tonsil cancers with aberrant p53 expression. EBV was detected by PCR in 11 biopsies, but in situ hybridisation and immunohistochemistry, did not confirm this finding. Aberrant p53 expression was observed in approximately half of the tumours. These results support the involvement of both aberrant p53 expression and HPV in the aetiology of squamous cell carcinoma of the head and neck.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1281-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Involvement of aberrant p53 expression and human papillomavirus in carcinoma of the head, neck and esophagus.
pubmed:affiliation
Department of Immunology, Microbiology, Pathology, Karolinska Institute, Huddinge Hospital, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't