| pubmed-article:8067515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8067515 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:8067515 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:8067515 | lifeskim:mentions | umls-concept:C1267213 | lld:lifeskim |
| pubmed-article:8067515 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:8067515 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8067515 | pubmed:dateCreated | 1994-9-19 | lld:pubmed |
| pubmed-article:8067515 | pubmed:abstractText | Recent studies have suggested a probable etiologic association between Epstein-Barr virus (EBV) and nasal lymphomas, irrespective of geographic location. This study was performed to investigate the strength of association of EBV with non-Hodgkin's lymphomas of the upper aerodigestive tract, based on a large series of cases that have been thoroughly immunophenotyped on frozen tissues. A sensitive in situ hybridization technique was used to detect EBV encoded RNA (EBER) in paraffin sections. Among 30 cases of nasal/nasopharyngeal T-cell lymphoma, 25 (83.3%) were EBER-positive. In the positive cases, most of the neoplastic cells showed strong nuclear signals. Further analysis of this group of tumors showed that all 21 cases (100%) with a CD56+ CD3-phenotype were EBER positive, whereas four of nine cases (44.4%) with a CD56-negative immunophenotype were positive. Only one of 10 cases (10%) of nasal/nasopharyngeal B-cell lymphoma was EBER positive; the positive case was a diffuse mixed-cell lymphoma and could not be distinguished morphologically from the negative cases. Among the 21 cases of lymphoma of the tonsils and back of the tongue (20 B-lineage and one T-lineage), none was EBER positive. In the normal mucosa of the nose/nasopharynx or tonsil (20 cases studied), only very rare EBER-positive small lymphocytes were found in two cases. The almost exclusive detection of EBER in nasal/nasopharyngeal T-cell neoplasms among the lymphomas of the upper aerodigestive tract suggests that EBV probably plays an etiologic role in the pathogenesis of this group of tumors and is not simply a passenger virus, and neither is this merely a site-dependent phenomenon in view of the weak association with nasal/nasopharyngeal B-cell lymphoma. | lld:pubmed |
| pubmed-article:8067515 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8067515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8067515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8067515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8067515 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8067515 | pubmed:issn | 0147-5185 | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:ChaoJ JJJ | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:PoonY FYF | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:YipT TTT | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:WongC CCC | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:NgC SCS | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:TsangW YWY | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:KayV FVF | lld:pubmed |
| pubmed-article:8067515 | pubmed:author | pubmed-author:VaiGG | lld:pubmed |
| pubmed-article:8067515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8067515 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:8067515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8067515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8067515 | pubmed:pagination | 938-46 | lld:pubmed |
| pubmed-article:8067515 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
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| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:meshHeading | pubmed-meshheading:8067515-... | lld:pubmed |
| pubmed-article:8067515 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8067515 | pubmed:articleTitle | Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract. | lld:pubmed |
| pubmed-article:8067515 | pubmed:affiliation | Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong. | lld:pubmed |
| pubmed-article:8067515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8067515 | pubmed:publicationType | Review | lld:pubmed |
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