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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1994-9-19
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pubmed:abstractText |
Recent studies have suggested a probable etiologic association between Epstein-Barr virus (EBV) and nasal lymphomas, irrespective of geographic location. This study was performed to investigate the strength of association of EBV with non-Hodgkin's lymphomas of the upper aerodigestive tract, based on a large series of cases that have been thoroughly immunophenotyped on frozen tissues. A sensitive in situ hybridization technique was used to detect EBV encoded RNA (EBER) in paraffin sections. Among 30 cases of nasal/nasopharyngeal T-cell lymphoma, 25 (83.3%) were EBER-positive. In the positive cases, most of the neoplastic cells showed strong nuclear signals. Further analysis of this group of tumors showed that all 21 cases (100%) with a CD56+ CD3-phenotype were EBER positive, whereas four of nine cases (44.4%) with a CD56-negative immunophenotype were positive. Only one of 10 cases (10%) of nasal/nasopharyngeal B-cell lymphoma was EBER positive; the positive case was a diffuse mixed-cell lymphoma and could not be distinguished morphologically from the negative cases. Among the 21 cases of lymphoma of the tonsils and back of the tongue (20 B-lineage and one T-lineage), none was EBER positive. In the normal mucosa of the nose/nasopharynx or tonsil (20 cases studied), only very rare EBER-positive small lymphocytes were found in two cases. The almost exclusive detection of EBER in nasal/nasopharyngeal T-cell neoplasms among the lymphomas of the upper aerodigestive tract suggests that EBV probably plays an etiologic role in the pathogenesis of this group of tumors and is not simply a passenger virus, and neither is this merely a site-dependent phenomenon in view of the weak association with nasal/nasopharyngeal B-cell lymphoma.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0147-5185
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
938-46
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:8067515-Herpesvirus 4, Human,
pubmed-meshheading:8067515-Humans,
pubmed-meshheading:8067515-Immunohistochemistry,
pubmed-meshheading:8067515-In Situ Hybridization,
pubmed-meshheading:8067515-Lymphoma,
pubmed-meshheading:8067515-Nasopharyngeal Neoplasms,
pubmed-meshheading:8067515-Nose Neoplasms,
pubmed-meshheading:8067515-RNA, Viral,
pubmed-meshheading:8067515-RNA-Binding Proteins,
pubmed-meshheading:8067515-Ribosomal Proteins,
pubmed-meshheading:8067515-Tonsillar Neoplasms
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pubmed:year |
1994
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pubmed:articleTitle |
Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract.
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pubmed:affiliation |
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
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pubmed:publicationType |
Journal Article,
Review
|