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pubmed:abstractText |
Since the exchange of gases, as well as metabolites, is greatly impeded in a paranasal sinus empyema, it is not unlikely that certain organic substances be retained and accumulated in purulent secretion. In this study, secretions aspirated from experimentally infected maxillary sinuses of 26 rabbits were analysed biochemically. Quantitatively, by far the most important acid accumulated in secretions was lactic acid. Lactate induces metabolic acidosis and exerts an inhibitory effect on mammalian defense mechanisms. Lactate may also be used as an energy source by certain microorganisms. In spite of its leukocytic origin lactic acid thus promotes the continuation of a bacterial infection. In addition, certain other organic acids of bacterial origin were found, which, in different ways, contribute to the impediment of antimicrobial defense functions.
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