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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5176
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pubmed:dateCreated |
1994-9-19
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pubmed:abstractText |
Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-Y Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/LMP7 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tap1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tap2 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
265
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1234-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8066463-ATP-Binding Cassette Transporters,
pubmed-meshheading:8066463-Amino Acid Sequence,
pubmed-meshheading:8066463-Animals,
pubmed-meshheading:8066463-Antigen Presentation,
pubmed-meshheading:8066463-Antigen-Presenting Cells,
pubmed-meshheading:8066463-Base Sequence,
pubmed-meshheading:8066463-Carrier Proteins,
pubmed-meshheading:8066463-Cysteine Endopeptidases,
pubmed-meshheading:8066463-Female,
pubmed-meshheading:8066463-Gene Deletion,
pubmed-meshheading:8066463-H-2 Antigens,
pubmed-meshheading:8066463-H-Y Antigen,
pubmed-meshheading:8066463-Lymphocytes,
pubmed-meshheading:8066463-Male,
pubmed-meshheading:8066463-Mice,
pubmed-meshheading:8066463-Mice, Knockout,
pubmed-meshheading:8066463-Molecular Sequence Data,
pubmed-meshheading:8066463-Multienzyme Complexes,
pubmed-meshheading:8066463-Proteasome Endopeptidase Complex,
pubmed-meshheading:8066463-Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
MHC class I expression in mice lacking the proteasome subunit LMP-7.
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pubmed:affiliation |
Basel Institute for Immunology, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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