Linked Life Data

8065734

Source:http://linkedlifedata.com/resource/pubmed/id/8065734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-9-20
pubmed:abstractText
We investigated the effect of methotrexate-induced neutropenia on periapical lesions in rats. Periapical lesions were prepared in all animals by pulpal exposure. The animals were injected with methotrexate three times a week 4 weeks before or after the pulpal exposure. The periapical lesion of each animal was examined histologically, histometrically, and immunohistochemically. The total leukocyte count and neutrophil count in the peripheral blood decreased after the injection. The methotrexate-induced neutropenia elicited after pulpal exposure did not change the status of the periapical lesion, whereas the neutropenia before the exposure inhibited the development of the lesion. Moreover, the neutropenia before pulpal exposure resulted in an inhibition of infiltration of neutrophils into the lesion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0030-4220
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-61
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effect of methotrexate-induced neutropenia on rat periapical lesion.
pubmed:affiliation
Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
pubmed:publicationType
Journal Article