Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-10-11
pubmed:abstractText
A rickettsia related to but distinct from the spotted fever agent, Rickettsia rickettsii, has been detected in 167 (18.9%) of 884 Rhipicephalus sanguineus taken off dogs in central and northern Mississippi. The organisms could readily be isolated in male meadow voles (Microtus pennsylvanicus), where it produced massive infections in the tissues of tunica vaginalis. It was practically nonpathogenic for male guinea pigs, although inoculation of these animals with infected tunica vaginalis of voles afforded in 30 of 38 instances solid immunity to challenge with virulent R. rickettsii. The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells. Cytopathogenic effects were minimal unless large concentrations of rickettsiae were used as inocula. It also could be established in embryonated hen eggs but only after injection of massive doses of L cell-propagated organisms. Serological tests (complement fixation, microagglutination and/or micro immunofluorescence) indicated that the newly described Rickettsia belongs to the spotted fever group but differs from R. rickettsii, R. akari, and R. conorii. Antigenic differences were also demonstrated by direct fluorescence microscopy as well as by vaccine potency and mouse-toxin neutralization tests.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2010-9-3
pubmed:meshHeading
pubmed-meshheading:806533-Animals, pubmed-meshheading:806533-Antigens, Bacterial, pubmed-meshheading:806533-Arvicolinae, pubmed-meshheading:806533-Bacterial Vaccines, pubmed-meshheading:806533-Bacteriological Techniques, pubmed-meshheading:806533-Centrifugation, Density Gradient, pubmed-meshheading:806533-Chick Embryo, pubmed-meshheading:806533-Culture Techniques, pubmed-meshheading:806533-Disease Vectors, pubmed-meshheading:806533-Female, pubmed-meshheading:806533-Fluorescent Antibody Technique, pubmed-meshheading:806533-Guinea Pigs, pubmed-meshheading:806533-Hemolymph, pubmed-meshheading:806533-Immunity, pubmed-meshheading:806533-Mississippi, pubmed-meshheading:806533-Neutralization Tests, pubmed-meshheading:806533-Rickettsia, pubmed-meshheading:806533-Rickettsia Infections, pubmed-meshheading:806533-Rickettsia rickettsii, pubmed-meshheading:806533-Rocky Mountain Spotted Fever, pubmed-meshheading:806533-Spleen, pubmed-meshheading:806533-Ticks, pubmed-meshheading:806533-United States, pubmed-meshheading:806533-Vagina, pubmed-meshheading:806533-Vaginal Diseases
pubmed:year
1975
pubmed:articleTitle
Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States.
pubmed:publicationType
Journal Article