Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-22
pubmed:abstractText
The T cell receptor (TCR)-alpha/beta CD4-8- (double negative, DN) T cell subset is characterized by an oligoclonal repertoire and a restricted V gene usage. By immunizing mice with a DN T cell clone we generated two monoclonal antibodies (mAbs) against V alpha 24 and V beta 11, which have been reported to be preferentially expressed in DN T cells. Using these antibodies, we could investigate the expression and pairing of these V alpha and V beta gene products among different T cell subsets. V alpha 24 is rarely expressed among CD4+ and especially CD8+ T cells. In these cases it is rearranged to different J alpha segments, carries N nucleotides, and pairs with different V beta. Remarkably, V alpha 24 is frequently expressed among DN T cells and is always present as an invariant rearrangement with J alpha Q, without N region diversity. This invariant V alpha 24 chain is always paired to V beta 11. This unique V alpha 24-J alpha Q/V beta 11 TCR was found in expanded DN clones from all the individuals tested. These findings suggest that the frequent occurrence of cells carrying this invariant TCR is due to peripheral expansion of rare clones after recognition of a nonpolymorphic ligand.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1281285, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1309556, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1323608, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1476601, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1512537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1586742, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1677392, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1831220, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-1832874, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-2110506, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-2374739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-2477705, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-3043226, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-3114646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-3117531, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-7505446, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-7520467, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-7684433, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8057043, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8211163, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8350060, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8356451, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8356452, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8383806, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8386744, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064234-8391057
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1171-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.
pubmed:affiliation
DIBIT, S. Raffaele Scientific Institute, Milano, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't