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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-9-22
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pubmed:abstractText |
We investigated whether human resting T cells could be activated to proliferate and display effector function in the absence of T cell receptor occupancy. We report that combination of interleukin 2 (IL-2), tumor necrosis factor alpha, and IL-6 activated highly purified naive (CD45RA+) and memory (CD45RO+) resting CD4+ T cells to proliferate. Under this condition, memory resting T cells could also display effector function as measured by lymphokine synthesis and help for immunoglobulin production by B cells. This novel Ag-independent pathway of T cell activation may play an important role in vivo in recruiting effector T cells at the site of immune response and in maintaining the clonal size of memory T cells in the absence of antigenic stimulation. Moreover, cytokines can induce proliferation of naive T cells without switch to memory phenotype and this may help the maintenance of the peripheral pool of naive T cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-1438221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-1696717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-1709845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-1972679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-1973388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2185780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2191683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2199284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2407536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2466079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2466769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2467293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2550551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2965180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2972769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-2987968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-3029221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-3499611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-8044459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-8100135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-8426116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064232-8453090
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1159-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8064232-Antigens, CD45,
pubmed-meshheading:8064232-Humans,
pubmed-meshheading:8064232-Immunologic Memory,
pubmed-meshheading:8064232-Interleukin-2,
pubmed-meshheading:8064232-Interleukin-6,
pubmed-meshheading:8064232-Lymphocyte Activation,
pubmed-meshheading:8064232-Receptors, Interleukin-2,
pubmed-meshheading:8064232-T-Lymphocytes,
pubmed-meshheading:8064232-Tumor Necrosis Factor-alpha
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pubmed:year |
1994
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pubmed:articleTitle |
Antigen-independent activation of naive and memory resting T cells by a cytokine combination.
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pubmed:affiliation |
Immunobiology Research Institute Siena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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