Linked Life Data

8064229

Source:http://linkedlifedata.com/resource/pubmed/id/8064229

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-22
pubmed:abstractText
Glomerular infiltration by neutrophils is a hallmark of acute glomerulonephritis. The pathophysiological role of interleukin 8 (IL-8), a potent neutrophil chemotactic cytokine (chemokine), was explored in an animal model of acute immune complex-mediated glomerulonephritis by administering a neutralizing antibody against IL-8. Repeated injection of bovine serum albumin (BSA) into rabbits caused the deposition of immune complexes consisting of BSA and rabbit IgG in glomeruli. Histological analyses revealed a small but significant number of neutrophils in glomeruli and the fusion of epithelial cell foot processes. Concomitantly, urinary levels of protein and albumin increased markedly (3.20 +/- 0.97 and 1.39 +/- 0.53 mg/h, respectively) compared with those of untreated animals (0.77 +/- 0.21 and 0.01 +/- 0.01 mg/h, respectively). Anti-IL-8 antibody treatment decreased the number of neutrophils in glomeruli by 40% and dramatically prevented the fusion of epithelial cell foot process. Furthermore, treatment with anti-IL-8 antibody completely normalized the urinary levels of protein and albumin (0.89 +/- 0.15 and 0.02 +/- 0.01 mg/h, respectively). These results indicated that IL-8 participated in the impairment of renal functions in experimental acute immune complex-mediated glomerulonephritis through activating as well as recruiting neutrophils.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-13022878, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-1567543, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-1745007, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-1910690, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-2968048, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-6090809, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-6266876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-6315851, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-7241057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-7339864, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-8347559, http://linkedlifedata.com/resource/pubmed/commentcorrection/8064229-874088
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1135-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis.
pubmed:affiliation
First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't