Linked Life Data

8062288

Source:http://linkedlifedata.com/resource/pubmed/id/8062288

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-9-19
pubmed:abstractText
The synthesis of the alpha and beta anomers of the title compound (1) was accomplished from D-mannose. In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosphonate under two-phase conditions. In vitro bioassays have shown that the beta anomer (1a) is a potent inhibitor of Ins(1,4,5)P3 3-kinase and inhibits other enzymes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-6215
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
260
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Synthesis and biological activities of (4,6-di-O-phosphonato-beta-D-mannopyranosyl)-methylphosphonate as an analogue of 1L-myo-inositol 1,4,5-trisphosphate.
pubmed:affiliation
Department of Chemistry, Pohang Institute of Science & Technology, Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't