Linked Life Data

8061219

Source:http://linkedlifedata.com/resource/pubmed/id/8061219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-9-21
pubmed:abstractText
Concentration profiles of 2.5 microns latex beads were measured to demonstrate lateral transport of platelet-sized objects in flows of blood suspensions; the flows had equivalent Poiseuille wall shear rates (WSRs) from 250 to 1220 s-1. Each experimental trial began with a steady flow of suspension without beads in a thin-walled capillary tube (219 microns ID; 10.2 microns SD). The tube entrance was then switched to a reservoir containing suspension of equal hematocrit, but with beads, for a short interval of flow at the same WSR. This process established a paraboloidal tongue of labeled suspension with a transient concentration gradient at its surface. The tube and contents were rapidly frozen to fix the suspended particles in flow-determined locations. Segments of frozen tube were collected at distances from the entrance corresponding to 13%, 39%, and 65% of the axial extent of the ideal paraboloidal tongue. Concentration profiles were estimated from distances measured on fluorescence microscope images of cross-cut tube segments. Experiments used tubes either 40 or 50 cm long, suspension hematocrits of 0, 15, or 40%, and bead concentrations in the range of 1.5-2.2 x 10(5)/mm3. Profiles for 0% hematocrit suspension, a dilute, single-component suspension, had features expected in normal diffusive mixing in a flow. Distinctly different profiles and more lateral transport occurred when the suspensions contained red cells; then, all profiles for 13% extent had regions of excess bead concentration near the wall. Suspension flows with 40% hematocrit exhibited the largest amount of lateral transport. A case is made that, to a first approximation, the rate of lateral transport grew linearly with WSR; however, statistical analysis showed that for 40% hematocrit, less lateral transport occurred when the WSR was 250 s-1 or 1220 s-1 than 560 s-1, thus indicating that the rate behavior is more complex.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-1883945, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-2302078, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-2597441, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-2624893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-3185301, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-3587076, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-3750272, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-3762431, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-5119364, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-5787985, http://linkedlifedata.com/resource/pubmed/commentcorrection/8061219-7184519
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1706-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Transient lateral transport of platelet-sized particles in flowing blood suspensions.
pubmed:affiliation
Department of Biomedical Engineering, University of Miami, Florida.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.