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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1994-9-14
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pubmed:abstractText |
gamma delta T cells respond to a variety of microbial pathogens and transformed cells. Their limited receptor repertoire and activation by mycobacterial antigens resistant to proteases suggest that they may recognize nonpeptide antigens. We have tested a variety of nonpeptide molecules for stimulation of human gamma delta T cells. Synthetic alkyl phosphates, particularly monoethyl phosphate (MEP), selectively activated gamma delta T cells and stimulated their proliferation in vitro. All gamma delta T cells stimulated by MEP expressed V gamma 2/V delta 2 receptors. The purified natural ligand of mycobacteria is chemically similar to, though distinct from, MEP and contains a phosphate residue that is critical for biological activity. Recognition and expansion of a specific T-cell receptor-bearing population to non-peptide ligands is unprecedented among T cells. We suggest that MEP mimics small natural ligands capable of expanding one subset of gamma delta T cells and that this recognition of nonpeptide antigens may play an important role in human immunity to pathogens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1281285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1352063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1353418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1386086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1531764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1533150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1534075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1535340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1650758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1650759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1651977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1658146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1658147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1684157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1827824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1831219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-1978758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2137854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2141570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2185330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2471938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2572670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-2968519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-3055853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-3459168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8146660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8353984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8361537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8393042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8476575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8058775-8477812
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8175-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8058775-Antibodies,
pubmed-meshheading:8058775-Antigens, Bacterial,
pubmed-meshheading:8058775-Arthritis, Rheumatoid,
pubmed-meshheading:8058775-Clone Cells,
pubmed-meshheading:8058775-Cytotoxicity, Immunologic,
pubmed-meshheading:8058775-Flow Cytometry,
pubmed-meshheading:8058775-Humans,
pubmed-meshheading:8058775-Ligands,
pubmed-meshheading:8058775-Lymphocyte Activation,
pubmed-meshheading:8058775-Mycobacterium tuberculosis,
pubmed-meshheading:8058775-Phosphoric Acid Esters,
pubmed-meshheading:8058775-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:8058775-Synovial Fluid,
pubmed-meshheading:8058775-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Nonpeptide ligands for human gamma delta T cells.
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pubmed:affiliation |
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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